She studied at Strathcona Baptist Girls Grammar School in Victoria.
After working in musical and theater, in 2012 Ruffle joined the cast of the TV series Mako Mermaids as one of the lead female characters.
In a magazine article, Jonathan M. Shiff said "Amy auditioned for all roles, but I immediately saw her as Sirena - the mermaid who is always trying to be the peacemaker Sirena was born very quickly"